Article
The contribution of rare variation to prostate cancer heritability.
Nature genetics - 1 Jan 2016
Mancuso Nicholas, Rohland Nadin, Rand Kristin A, Tandon Arti, Allen Alexander, Quinque Dominique, Mallick Swapan, Li Heng, Stram Alex, Sheng Xin, Kote-Jarai Zsofia, Easton Douglas F, Eeles Rosalind A, Le Marchand Loic, Lubwama Alex, Stram Daniel, Watya Stephen, Conti David V, Henderson Brian, Haiman Christopher A, Pasaniuc Bogdan, Reich David
Abstract excerpt
We report targeted sequencing of 63 known prostate cancer risk regions in a multi-ancestry study of 9,237 men and use the data to explore the contribution of low-frequency variation to disease risk. We show that SNPs with minor allele frequencies (MAFs) of 0.1-1% explain a substantial fraction of prostate cancer risk in men of African ancestry. We estimate that these SNPs account for 0.12 (standard error (s.e.) =...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.