Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

doi:10.1158/1055-9965.EPI-13-0889

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Article

Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2014

Knipe Duleeka W, Evans David M, Kemp John P, Eeles Rosalind, Easton Douglas F, Kote-Jarai Zsofia, Al Olama Ali Amin, Benlloch Sara, Donovan Jenny L, Hamdy Freddie C, Neal David E, Smith George Davey, Lathrop Mark, Martin Richard M

Abstract excerpt

BACKGROUND: Only a minority of the genetic components of prostate cancer risk have been explained. Some observed associations of SNPs with prostate cancer might arise from associations of these SNPs with circulating prostate-specific antigen (PSA) because PSA values are used to select controls. METHODS: We undertook a genome-wide association study (GWAS) of screen-detected prostate cancer (ProtecT: 1,146 cases...

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PMID: 24753544
DOI: 10.1158/1055-9965.EPI-13-0889
PMCID: PMC4082405

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