Article
Polygenic overlap between kidney function and large artery atherosclerotic stroke.
Stroke - 1 Dec 2014
Holliday Elizabeth G, Traylor Matthew, Malik Rainer, Bevan Stephen, Maguire Jane, Koblar Simon A, Sturm Jonathan, Hankey Graeme J, Oldmeadow Christopher, McEvoy Mark, Sudlow Cathie, Rothwell Peter M, Coresh Josef, Hamet Pavel, Tremblay Johanne, Turner Stephen T, de Andrade Mariza, Rao Madhumathi, Schmidt Reinhold, Crick Peter A, Robino Antonietta, Peralta Carmen A, Jukema J Wouter, Mitchell Paul, Rosas Sylvia E, Wang Jie Jin, Scott Rodney J, Dichgans Martin, Mitchell Braxton D, Kao W H Linda, Fox Caroline S, Levi Christopher, Attia John, Markus Hugh S
Abstract excerpt
BACKGROUND AND PURPOSE: Epidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes. METHODS: Polygenic models were derived using genome-wide association...
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