Article
Polygenic risk of ischemic stroke is associated with cognitive ability.
Neurology - 16 Feb 2016
Harris Sarah E, Malik Rainer, Marioni Riccardo, Campbell Archie, Seshadri Sudha, Worrall Bradford B, Sudlow Cathie L M, Hayward Caroline, Bastin Mark E, Starr John M, Porteous David J, Wardlaw Joanna M, Deary Ian J
Abstract excerpt
OBJECTIVES: We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish cohorts: the Lothian Birth Cohort 1936 (LBC1936), the Lothian Birth Cohort 1921 (LBC1921), and Generation Scotland: Scottish Family Health Study (GS). METHODS: Polygenic risk scores for ischemic stroke were created in LBC1936 (n = 1005), LBC1921 (n = 517),...
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