Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium.

doi:10.1053/j.ajkd.2012.12.024

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Article

Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jun 2013

Olden Matthias, Teumer Alexander, Bochud Murielle, Pattaro Cristian, Köttgen Anna, Turner Stephen T, Rettig Rainer, Chen Ming-Huei, Dehghan Abbas, Bastardot Francois, Schmidt Reinhold, Vollenweider Peter, Schunkert Heribert, Reilly Muredach P, Fornage Myriam, Launer Lenore J, Verwoert Germaine C, Mitchell Gary F, Bis Joshua C, O'Donnell Christopher J, Cheng Ching-Yu, Sim Xueling, Siscovick David S, Coresh Josef, Kao W H Linda, Fox Caroline S, O'Seaghdha Conall M

Abstract excerpt

BACKGROUND: Chronic kidney disease is associated with cardiovascular disease. We tested for evidence of a shared genetic basis to these traits. STUDY DESIGN: We conducted 2 targeted analyses. First, we examined whether known single-nucleotide polymorphisms (SNPs) underpinning kidney traits were associated with a series of vascular phenotypes. Additionally, we tested whether vascular SNPs were associated with...

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Identifiers

PMID: 23474010
DOI: 10.1053/j.ajkd.2012.12.024
PMCID: PMC3660426

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