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Article

[BRAF-V600E mutation and its clinical significance in children with Langerhans cell histiocytosis].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 1 Apr 2018

Tang Xue, Guo Xia, Sun Lin-Yong, Ai Yuan, Yang Xue, Sun Jing-Jing, Wu Jian-Rong, Gao Ju

Abstract excerpt

OBJECTIVE: To investigate the clinical significance of BRAF-V600E mutation in children with Langerhans cell histiocytosis (LCH). METHODS: Real-time fluorescence quantitative PCR was used to detect BRAF-V600E mutation in paraffin-embedded tissue samples from 26 children with LCH. A retrospective analysis was performed for the association of BRAF-V600E mutation with clinical features and prognosis of children with...

Topics

Adolescent
Child
Child, Preschool
Female
Histiocytosis, Langerhans-Cell
Humans
Infant
Male
Mutation
Proto-Oncogene Proteins B-raf
Retrospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 29658453
PMCID: PMC7390037

Genes

BRAF
EFS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29658453-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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