Identification of the V600D mutation in Exon 15 of the <i>BRAF</i> oncogene in congenital, benign langerhans cell histiocytosis

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a well-known but rare disease that may occur at any age with markedly variable clinical features: self-regressive, localized, multiorgan, aggressive, or fatal outcome. Congenital LCH is rare and often clinically benign. While LCH is characterized by a clonal proliferation of Langerhans cells, its etiology is unknown. Although BRAF V600E mutations were recently identified as...

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