Prevalence of the BRAF V600E mutation in Greek adults with Langerhans cell histiocytosis.

doi:10.1080/08880018.2022.2029988

Article

Prevalence of the BRAF V600E mutation in Greek adults with Langerhans cell histiocytosis.

Pediatric hematology and oncology - 1 Sept 2022

Stathi Dimitra, Yavropoulou Maria P, Allen Carl E, Abhyankar Harshal, Scull Brooks, Tsoli Marina, Andreakos Evangelos, Kaltsas Gregory, Makras Polyzois

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasia with a broad spectrum of clinical manifestations. The activation of the MAP kinase pathway plays an integral role in its pathogenesis with genetic alterations found in the majority of cases that most frequently involve a...

Topics

Adult
Child
Greece
Histiocytosis, Langerhans-Cell
Humans
Mutation
Prevalence
Proto-Oncogene Proteins B-raf

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