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Article

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

27 Oct 2014

Abstract excerpt

Neural stem cells are multipotent cells with the ability to differentiate into neurons, astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the mechanical properties of the cellular environment. However, molecular pathways transducing matrix mechanical cues to intracellular signaling pathways linked to lineage specification remain unclear. We found that the mechanically gated ion...

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PMID: 25349416
DOI: 10.1073/pnas.1409802111

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