Article
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.
Nature - 1 Mar 2018
He Li, Si Guangwei, Huang Jiuhong, Samuel Aravinthan D T, Perrimon Norbert
Abstract excerpt
Somatic stem cells constantly adjust their self-renewal and lineage commitment by integrating various environmental cues to maintain tissue homeostasis. Although numerous chemical and biological signals have been identified that regulate stem-cell behaviour, whether stem cells can directly sense mechanical signals in vivo remains unclear. Here we show that mechanical stress regulates stem-cell differentiation in...
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