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Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids

2025-10-22

Abstract excerpt

Heartbeat sound is one of the first rhythmic stimuli encountered by the developing human brain, yet its biological role has remained unexplored. Here we show that heartbeat sound promotes structural and functional maturation of human cortical organoids with a physiological astrocyte-to-neuron ratio. Continuous stimulation with heartbeat expanded the extracellular space (ECS), visualized by super-resolution 3D STED...

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Literature Corpus work
7e294a57-5139-5eed-a1bf-7719750670c2
DOI
10.1101/2025.10.21.683816
Open publication

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Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoidsDOI 10.1101/2025.10.21.683816
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