Article

Mechanical stretch disrupts calcium dynamics and redistributes Piezo1 in human astrocytes

2025-10-09

Abstract excerpt

Astrocytes regulate the activity of nearby neurons so disruption of astrocyte calcium dynamics by traumatic brain injury (TBI) could have profound consequences for neural network activity in the brain. In this study, human induced pluripotent stem cell (hiPSC)-derived astrocytes were used in a two-dimensional (2D) in vitro stretch injury model to evaluate the effect of trauma on calcium dynamics, mitochondrial fu...

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Literature Corpus work: 556d106f-6a32-53f6-8f68-82e853f8b399
DOI: 10.1101/2025.10.08.681038

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