Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis

Abstract excerpt

Mechanical stimuli, such as stretch and resistance training, are essential in regulating the growth and functioning of skeletal muscles. However, the molecular mechanisms involved in sensing mechanical stress during muscle formation remain unclear. Here, we investigated the role of the mechanosensitive ion channel Piezo1 during myogenic progression of both fast and slow muscle satellite cells. We found that Piezo1...

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• Erythrocyte Function and Pathophysiology
• Exercise and Physiological Responses
• Ion channel regulation and function

Identifiers and source

Literature Corpus work

5ded239d-6938-51f0-9a2e-739a35c98c71

DOI

10.3390/cells11030393