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Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states

18 Mar 2022

Abstract excerpt

Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the potential contribution of MuSC morphology to in vivo function remains unknown. Here, we demonstrate that quiescent MuSCs are morphologically heterogeneous and exhibit different patterns of cellular protrusions. We classified quiescent MuSCs into three functionally distinct stem cell states: responsive, intermediate, and...

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PMID: 35302846
DOI: 10.1126/sciadv.abn0485

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