Article
The CpG island methylator phenotype in breast cancer is associated with the lobular subtype.
Epigenomics - 1 Jan 2015
Roessler Jessica, Ammerpohl Ole, Gutwein Jana, Steinemann Doris, Schlegelberger Brigitte, Weyer Veronika, Sariyar Murat, Geffers Robert, Arnold Norbert, Schmutzler Rita, Bartram Claus R, Heinrich Tilman, Abbas Mahmoud, Antonopoulos Wiebke, Schipper Elisa, Hasemeier Britta, Kreipe Hans, Lehmann Ulrich
Abstract excerpt
BACKGROUND: Aberrations in DNA methylation patterns are well-described in human malignancies. However, the existence of the 'CpG island methylator phenotype' (CIMP) in human breast cancer is still controversial. MATERIALS & METHODS: Illumina's HumanMethylation 450K BeadChip was used to analyze genome-wide DNA methylation patterns. Chromosomal abnormalities were determined by array-based CGH. RESULTS: Invasive...
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