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Article

Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns.

Breast cancer research : BCR - 1 Jan 2010

Holm Karolina, Hegardt Cecilia, Staaf Johan, Vallon-Christersson Johan, Jönsson Göran, Olsson Håkan, Borg Ake, Ringnér Markus

Abstract excerpt

INTRODUCTION: Five different molecular subtypes of breast cancer have been identified through gene expression profiling. Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct methylation profiles. METHODS: We analysed methylation status of 807 cancer-related genes in 189 fresh frozen primary...

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Identifiers

PMID: 20565864
DOI: 10.1186/bcr2590
PMCID: PMC2917031

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BRCA2

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