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Article

CDH1 methylation analysis in invasive lobular breast carcinomas with and without gene mutation.

Virchows Archiv : an international journal of pathology - 1 Aug 2024

González-Martínez Silvia, Kajabova Viera Horvathova, Pérez-Mies Belén, Carretero-Barrio Irene, Caniego-Casas Tamara, Sarrió David, Moreno-Bueno Gema, Gión María, Perez-García José, Cortés Javier, Smolkova Bozena, Palacios José

Abstract excerpt

The proposed role of CDH1 (E-cadherin gene) methylation as a mechanism of gene inactivation in invasive lobular carcinoma (ILC) remains inconclusive. For many years, CDH1 promoter hypermethylation has been regarded as a mechanism for gene inactivation in ILC. However, this assumption has primarily relied on non-quantitative assays, which have reported CDH1 methylation frequencies ranging from 26 to 93% at CpG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38713384
DOI: 10.1007/s00428-024-03814-8
PMCID: PMC11329400

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