Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<scp>HOPX</scp> is methylated and exerts tumour‐suppressive function through Ras‐induced senescence in human lung cancer

24 Oct 2014

Abstract excerpt

HOPX acts as a tumour suppressor in various cancers. However, the regulation of HOPX in human lung cancer as well as the mechanism underlying its tumour-suppressive function has not yet been well elucidated. Here we investigated the epigenetic regulation and molecular mechanism by which HOPX exerts growth inhibitory effects. We found that HOPX was down-regulated in 12 out of 13 lung cancer cell lines and in 69...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25345926
DOI: 10.1002/path.4469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<scp>HOPX</scp> is methylated and exerts tumour‐suppressive function through Ras‐induced senescence in human lung cancerPMID 25345926Read ↗

Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer.Semantic proximity Read ↗

Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancerSemantic proximity Read ↗

HOPX Is an Epigenetically Inactivated Tumor Suppressor and Overexpression of HOPX Induce Apoptosis and Cell Cycle Arrest in Breast CancerSemantic proximity Read ↗

EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cellsSemantic proximity Read ↗

MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB1Semantic proximity Read ↗

Expression profiles of SV40‐immortalization‐associated genes upregulated in various human cancersSemantic proximity Read ↗

HOPX homeobox methylation in differentiated thyroid cancer and its clinical relevanceSemantic proximity Read ↗

ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformationSemantic proximity Read ↗

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathwaySemantic proximity Read ↗

miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancerSemantic proximity Read ↗

Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis.Semantic proximity Read ↗

EGFR and Ras regulate DDX59 during lung cancer development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.