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Article

Expression profiles of SV40‐immortalization‐associated genes upregulated in various human cancers

21 Jan 2009

Abstract excerpt

Immortalization is an early and essential step of human carcinogenesis which is associated with alterations in gene expression and regulation. Suppression subtractive hybridization (SSH) was successfully performed to identify immortalization-associated genes upregulated in SV40-immortalized lung fibroblasts. We identified 116 known genes which were related to diverse functions, with 32.8% relevant for cell cycle...

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PMID: 19160420
DOI: 10.1002/jcb.22063

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