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Article

Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis.

BMC cancer - 7 Sept 2012

Waraya Mina, Yamashita Keishi, Katoh Hiroshi, Ooki Akira, Kawamata Hiroshi, Nishimiya Hiroshi, Nakamura Kazunori, Ema Akira, Watanabe Masahiko

Abstract excerpt

BACKGROUND: We have recently identified HOP hoemobox (HOPX) as a tumor suppressor gene candidate, characterized by tumor-specific promoter DNA hypermethylation in human cancers, and it can remarkably inhibit tumors' aggressive phenotypes. In this current study, we for the first time examined methylation level of HOPX and tested the functional relevance in pancreatic cancer (PC). METHODS: Clinical features of HOPX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22958219
DOI: 10.1186/1471-2407-12-397
PMCID: PMC3488580

Genes

HOPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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