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Article

Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer.

Cancer letters - 1 Jan 2017

Kikuchi Mariko, Katoh Hiroshi, Waraya Mina, Tanaka Yoko, Ishii Satoru, Tanaka Toshimichi, Nishizawa Nobuyuki, Yokoi Keigo, Minatani Naoko, Ema Akira, Kosaka Yoshimasa, Tanino Hirokazu, Yamashita Keishi, Watanabe Masahiko

Abstract excerpt

Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, the aim of this study is to seek into the roles and clinical relevance of epigenetic silencing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27756570
DOI: 10.1016/j.canlet.2016.10.017

Genes

HOPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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