Article
EGFR and Ras regulate DDX59 during lung cancer development.
Gene - 5 Feb 2018
Yang Lin, Zhang Hanyin, Chen Dan, Ding Peikun, Yuan Yunchang, Zhang Yandong
Abstract excerpt
Oncogenes EGFR and ras are frequently mutated and activated in human lung cancers. In this report, we found that both EGFR and Ras signaling can upregulate RNA helicase DDX59 in lung cancer cells. DDX59 can be induced through the mitogen activated protein kinase (MAPK) pathway after EGFR or Ras activation. Inhibitors for Ras/Raf/MAP pathway significantly decreased DDX59 expression at both protein and mRNA levels....
Topics
- Animals
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- ErbB Receptors
- Female
- Gene Expression Regulation, Neoplastic
- HEK293 Cells
- Humans
- Lung Neoplasms
- Mice
- Mutation