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Article

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.

Genes & development - 15 Nov 2014

Zimmermann Michal, Kibe Tatsuya, Kabir Shaheen, de Lange Titia

Abstract excerpt

The semiconservative replication of telomeres is facilitated by the shelterin component TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon S-phase progression, fragile metaphase telomeres that resemble the common fragile sites (CFSs), and the association of sister telomeres. In contrast, TRF1 does not contribute significantly to the end protection functions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25344324
DOI: 10.1101/gad.251611.114
PMCID: PMC4233241

Genes

BLM
ATR
TPP1
POT1

Provenance

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