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Telomere maintenance and the DNA damage response: a paradoxical alliance

17 Oct 2024

Abstract excerpt

Telomeres are the protective caps at the ends of linear chromosomes of eukaryotic organisms. Telomere binding proteins, including the six components of the complex known as shelterin, mediate the protective function of telomeres. They do this by suppressing many arms of the canonical DNA damage response, thereby preventing inappropriate fusion, resection and recombination of telomeres. One way this is achieved is...

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PMID: 39483338
DOI: 10.3389/fcell.2024.1472906

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