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Article

Decreasing mitochondrial fission prevents cholestatic liver injury.

The Journal of biological chemistry - 5 Dec 2014

Yu Tianzheng, Wang Li, Lee Hakjoo, O'Brien Dawn K, Bronk Steven F, Gores Gregory J, Yoon Yisang

Abstract excerpt

Mitochondria frequently change their shape through fission and fusion in response to physiological stimuli as well as pathological insults. Disrupted mitochondrial morphology has been observed in cholestatic liver disease. However, the role of mitochondrial shape change in cholestasis is not defined. In this study, using in vitro and in vivo models of bile acid-induced liver injury, we investigated the...

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Identifiers

PMID: 25342755
DOI: 10.1074/jbc.M114.588616
PMCID: PMC4256342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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