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Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver

26 Feb 2022

Abstract excerpt

Non-alcoholic steatohepatitis (NASH) is a most common chronic liver disease that is manifested by steatosis, inflammation, fibrosis, and tissue damage. Hepatocytes produce giant mitochondria termed megamitochondria in patients with NASH. It has been shown that gene knockout of OPA1, a mitochondrial dynamin-related GTPase that mediates mitochondrial fusion, prevents megamitochondria formation and liver damage in a...

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PMID: 35310936
DOI: 10.1016/j.isci.2022.103996

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