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Article

Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation.

American journal of physiology. Cell physiology - 1 Apr 2012

Johnson David, Allman Erik, Nehrke Keith

Abstract excerpt

Mitochondrial morphology is determined by the balance between the opposing processes of fission and fusion, each of which is regulated by a distinct set of proteins. Abnormalities in mitochondrial dynamics have been associated with a variety of diseases, including neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, and dominant optic atrophy. Although the genetic determinants of fission...

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Identifiers

PMID: 22237403
DOI: 10.1152/ajpcell.00411.2011
PMCID: PMC3330737

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