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Article

Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase.

The Journal of biological chemistry - 5 Dec 2014

Edwards Daniel J, Streich Frederick C, Ronchi Virginia P, Todaro Dustin R, Haas Arthur L

Abstract excerpt

The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohort of effector proteins via a type III secretion system. The IpaH family of 10 such effectors mimics ubiquitin ligases but bears no sequence or structural homology to their eukaryotic counterpoints. Using rates of (125)I-polyubiquitin chain formation as a functional read out, IpaH9.8 displays V-type positive cooperativity...

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Identifiers

PMID: 25342744
DOI: 10.1074/jbc.M114.609164
PMCID: PMC4256345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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