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Article

Conserved Structural Mechanisms for Autoinhibition in IpaH Ubiquitin Ligases

8 Nov 2011

Abstract excerpt

The IpaH family of novel E3 ligase (NEL) enzymes occur in a variety of pathogenic and commensal bacteria that interact with eukaryotic hosts. We demonstrate that the leucine-rich repeat (LRR) substrate recognition domains of different IpaH enzymes autoinhibit the enzymatic activity of the adjacent catalytic novel E3 ligase domain by two distinct but conserved structural mechanisms. Autoinhibition is required for...

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PMID: 22065585
DOI: 10.1074/jbc.m111.316265

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