Article
The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Molecular cell - 21 Jul 2016
Pruneda Jonathan N, Durkin Charlotte H, Geurink Paul P, Ovaa Huib, Santhanam Balaji, Holden David W, Komander David
Abstract excerpt
Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways, often in creative ways. CE clan proteases, specific hydrolases for ubiquitin-like modifications (SUMO and NEDD8) in eukaryotes, reportedly serve as bacterial effector proteins with deSUMOylase, deubiquitinase, or, even, acetyltransferase activities. Here, we characterize bacterial CE protease activities, revealing...
Topics
- Amino Acid Sequence
- Bacteria
- Bacterial Proteins
- Chlamydia trachomatis
- Computational Biology
- Conserved Sequence
- Databases, Protein
- Escherichia coli
- HeLa Cells
- Humans
- Legionella
- Models, Molecular
- Mutation
- Phylogeny