Article

Chromosome-encoded IpaH ubiquitin ligases indicate non-human pathogenic <i>Escherichia</i>

2021-10-19

Abstract excerpt

Until recently, Shigella and enteroinvasive Escherichia coli were thought to be primate-restricted pathogens. The base of their pathogenicity is the type 3 secretion system (T3SS) encoded by the pINV virulence plasmid, which facilitates host cell invasion and subsequent proliferation. A large family of T3SS effectors, E3 ubiquitin-ligases encoded by the ipaH genes, have a key role in the Shigella pathogenicit...

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Literature Corpus work: c7e4bbfc-74cc-56de-ba78-0ea670784593
DOI: 10.1101/2021.10.19.464960

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