Article

Engineered Ubiquitin Variants Mitigate Pathogenic Bacterial Ubiquitin Ligase Function

2024-05-01

Abstract excerpt

During infection some pathogenic gram-negative bacteria, such as Salmonella , manipulate the host ubiquitination system through the delivery of secreted effectors known as novel E3 ubiquitin ligases (NELs). Despite the presence of NELs amongst these well-studied bacterial species, their unique structure has limited the tools that are available to probe their molecular mechanisms and explore their therapeutic pote...

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Literature Corpus work: 450ed37d-3d47-55fc-99d9-b1c51bd7db18
DOI: 10.1101/2024.05.01.592009

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