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Article

Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8

19 Jun 2019

Abstract excerpt

The guanylate-binding proteins (GBPs) belong to the dynamin superfamily of GTPases and function in cell-autonomous defense against intracellular pathogens.IpaH9.8, an E3 ligase from the pathogenic bacterium Shigella flexneri, ubiquitinates a subset of GBPs and leads to their proteasomal degradation.Here we report the structure of a C-terminally truncated GBP1 in complex with the IpaH9.8Leucine-rich repeat (LRR)...

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PMID: 31216343
DOI: 10.1371/journal.ppat.1007876

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