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Article

Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.

Molecular and cellular biology - 1 Feb 2014

Keszei Alexander F A, Tang Xiaojing, McCormick Craig, Zeqiraj Elton, Rohde John R, Tyers Mike, Sicheri Frank

Abstract excerpt

IpaH proteins are bacterium-specific E3 enzymes that function as type three secretion system (T3SS) effectors in Salmonella, Shigella, and other Gram-negative bacteria. IpaH enzymes recruit host substrates for ubiquitination via a leucine-rich repeat (LRR) domain, which can inhibit the catalytic domain in the absence of substrate. The basis for substrate recognition and the alleviation of autoinhibition upon...

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Identifiers

PMID: 24248594
DOI: 10.1128/MCB.01360-13
PMCID: PMC3911519

Genes

PKN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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