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Article

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans.

PLoS genetics - 1 Feb 2021

Pandey Pratima, Singh Anuradha, Kaur Harjot, Ghosh-Roy Anindya, Babu Kavita

Abstract excerpt

Ethanol is a widely used drug, excessive consumption of which could lead to medical conditions with diverse symptoms. Ethanol abuse causes dysfunction of memory, attention, speech and locomotion across species. Dopamine signaling plays an essential role in ethanol dependent behaviors in animals ranging from C. elegans to humans. We devised an ethanol dependent assay in which mutants in the dopamine autoreceptor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33524034
DOI: 10.1371/journal.pgen.1009346
PMCID: PMC7877767

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