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Article

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells

19 Feb 2015

Abstract excerpt

Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unknown. We report here that quiescence exit kinetics are differentially regulated within human HSC...

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PMID: 25704240
DOI: 10.1016/j.stem.2015.01.017

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