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Targeting cell cycle regulators in hematologic malignancies

9 Apr 2015

Abstract excerpt

Hematologic malignancies represent the fourth most frequently diagnosed cancer in economically developed countries. In hematologic malignancies normal hematopoiesis is interrupted by uncontrolled growth of a genetically altered stem or progenitor cell (HSPC) that maintains its ability of self-renewal. Cyclin-dependent kinases (CDKs) not only regulate the mammalian cell cycle, but also influence other vital...

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PMID: 25914884
DOI: 10.3389/fcell.2015.00016

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