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Article

Cyclin C Regulates Human Hematopoietic Stem/Progenitor Cell Quiescence

4 Dec 2009

Abstract excerpt

Hematopoietic stem cells (HSCs) can remain quiescent or they can enter the cell cycle, and either self-renew or differentiate. Although cyclin C and cyclin dependent kinase (cdk3) are essential for the transition from the G(0) to the G(1) phase of the cell cycle in human fibroblasts, the role of cyclin C in hematopoietic stem/progenitor cells (HSPCs) is not clear. We have identified an important role of cyclin C...

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PMID: 19967789
DOI: 10.1002/stem.270

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