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Article

Mixed adenoneuroendocrine carcinomas of the gastrointestinal tract: targeted next-generation sequencing suggests a monoclonal origin of the two components.

Neuroendocrinology - 1 Jan 2014

Scardoni Maria, Vittoria Emanuele, Volante Marco, Rusev Borislav, Bersani Samantha, Mafficini Andrea, Gottardi Marisa, Giandomenico Valeria, Malleo Giuseppe, Butturini Giovanni, Cingarlini Sara, Fassan Matteo, Scarpa Aldo

Abstract excerpt

BACKGROUND: Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract are rare neoplasms characterized by coexisting exocrine and neuroendocrine neoplastic components. MANECs' histogenetic classification and molecular characterization remain unclear, significantly affecting the identification of innovative therapeutic options for these tumors. METHODS: The exocrine and neuroendocrine components...

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Source

Identifiers

PMID: 25342539
DOI: 10.1159/000369071

Genes

ATM
CTNNB1
ERBB4
JAK3
KDR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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