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Article

Concept of neuroendocrine neoplasms of all organs with a focus on grading, subtyping.

Virchows Archiv : an international journal of pathology - 1 Jan 2026

Kasajima Atsuko, Perren Aurel, Klöppel Günter

Abstract excerpt

Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplasms encompassing both well differentiate neuroendocrine tumors (NETs), and poorly differentiated neuroendocrine carcinomas (NECs). This classification is supported by distinct histological, clinical, and molecular profiles. NETs are typically slow-growing and hormone-producing, with organoid architecture and frequent associations with hereditary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41483302
DOI: 10.1007/s00428-025-04296-y
PMCID: PMC12876108

Genes

MEN1
TP53
ATRX
DAXX
RB1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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