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Exploring Intratumoral Heterogeneity in Mixed Neuroendocrine-Nonneuroendocrine Neoplasms with Spatial Transcriptomics: Even More Diverse Than Anticipated

20 Aug 2025

Abstract excerpt

Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNEN) are usually highly aggressive tumors characterized by marked histological heterogeneity, most commonly represented by mixed adenocarcinoma and poorly differentiated neuroendocrine carcinoma (NEC). However, beyond morphological observations, the biological basis and implications of this heterogeneity remain incompletely understood. In this study, we combined...

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Lung Cancer Research Studies
Neuroendocrine Tumor Research Advances
Pancreatic and Hepatic Oncology Research

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PMID: 40833530
DOI: 10.1007/s12022-025-09869-w

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