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Article

Origin and evolution of colorectal mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN).

Endocrine-related cancer - 1 Jul 2026

Morken Siren, Sorbye Halfdan, Deng Wei, Dogramaci Hatice Toprak, Venizelos Andreas, Weber Vestermark Lene, Pfeiffer Per, Kersten Christian, Perren Aurel, Knappskog Stian

Abstract excerpt

GRAPHICAL ABSTRACT: ABSTRACT: Colorectal neuroendocrine carcinoma (NEC) is a rare and aggressive cancer and in a subset of patients associated with an adenocarcinoma (AC) component. When both components exceed 30% of the tumour, it is classified as mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN), although there is an ongoing debate about whether any presence of two distinct components should be...

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Source

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Identifiers

PMID: 42439376
DOI: 10.1530/ERC-26-0170
PMCID: PMC13428015

Genes

APC
BRAF
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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