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Article

Unraveling molecular pathways of poorly differentiated neuroendocrine carcinomas of the gastroenteropancreatic system: A systematic review.

Cancer treatment reviews - 1 May 2017

Girardi Daniel M, Silva Andrea C B, Rêgo Juliana Florinda M, Coudry Renata A, Riechelmann Rachel P

Abstract excerpt

BACKGROUND: Poorly differentiated neuroendocrine carcinomas (NECs) are rare and aggressive tumors. Their molecular pathogenesis is still largely unknown, and consequently, the best therapeutic management also remains to be determined. We conducted a systematic review on molecular alterations found in gastroenteropancreatic NECs (GEP-NECs) and discuss potential applications of targeted therapies in setting....

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Source

Identifiers

PMID: 28456055
DOI: 10.1016/j.ctrv.2017.04.002

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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