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Article

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.

Nature medicine - 1 Jan 2007

Fischer Will, Perkins Simon, Theiler James, Bhattacharya Tanmoy, Yusim Karina, Funkhouser Robert, Kuiken Carla, Haynes Barton, Letvin Norman L, Walker Bruce D, Hahn Beatrice H, Korber Bette T

Abstract excerpt

HIV-1/AIDS vaccines must address the extreme diversity of HIV-1. We have designed new polyvalent vaccine antigens comprised of sets of 'mosaic' proteins, assembled from fragments of natural sequences via a computational optimization method. Mosaic proteins resemble natural proteins, and a mosaic set maximizes the coverage of potential T-cell epitopes (peptides of nine amino acids) for a viral population. We found...

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PMID: 17187074
DOI: 10.1038/nm1461

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