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Article

Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months

30 Jan 2019

Abstract excerpt

BACKGROUND: Behaviour problems are prevalent among children born very preterm (≤ 32 weeks gestation), and have been associated with morphine exposure. Morphine accumulation in the brain is determined by genetic variations related to morphine biotransformation. The objective of the study was to investigate whether morphine-biotransformation genotypes contribute to individual differences in long-term effects of...

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PMID: 30709768
DOI: 10.1016/j.ebiom.2019.01.042

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