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Article

What can we learn from genetic studies of systemic lupus erythematosus? Implications of genetic heterogeneity among populations in SLE.

Lupus - 1 Oct 2010

Lee H-S, Bae S-C

Abstract excerpt

Recent progress in genetics has expanded the number of the genes associated with SLE to more than 20 in the past 2 years. One might assign these candidate genetic factors into several pre-existing biological pathways: (i) innate immune response including TLR/interferon signaling pathways (IRF5, STAT4, TNFAIP3, and TREX1); (ii) adaptive immune response (HLA-DR, PTPN22, PDCD1, STAT4, LYN, BLK, and BANK1) including...

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Topics

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Share to ATG5 gene
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Share to IRAK1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TREX1 gene

Share to Genetic Heterogeneity

Share to Genetic Predisposition to Disease

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 20947557
DOI: 10.1177/0961203310370350

Genes

STAT4
BLK
ITGAM
LYN
PTPN22
PXK
TNFAIP3
ATG5
CRP
IRAK1
MECP2
PDCD1
TREX1
XKR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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