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Article

Role of compartmentalization on HiF-1α degradation dynamics during changing oxygen conditions: a computational approach.

PloS one - 1 Jan 2014

Bedessem Baptiste, Stéphanou Angélique

Abstract excerpt

HiF-1α is the central protein driving the cellular response to hypoxia. Its accumulation in cancer cells is linked to the appearance of chemoresistant and aggressive tumor phenotypes. As a consequence, understanding the regulation of HiF-1α dynamics is a major issue to design new anti-cancer therapies. In this paper, we propose a model of the hypoxia pathway, involving HiF-1α and its inhibitor pVHL. Based on data...

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Identifiers

PMID: 25338163
DOI: 10.1371/journal.pone.0110495
PMCID: PMC4206521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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