Article
Single-cell imaging and mathematical modelling of the hypoxia-inducible factor signalling network
2011-01-01
Abstract excerpt
Hypoxia-inducible Factor (HIF) is an oxygen-sensitive transcription factor present in all multicellular life, including humans. It is responsible for mediating the cellular response to hypoxia, a situation in which oxygen supply falls below adequate levels. In the presence of oxygen HIF is constitutively degraded and inactivated. In the absence or reduction of oxygen, HIF escapes degradation and accumulates. Once...
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Identifiers and source
- Literature Corpus work
- fdb9341c-b9bf-5ac4-9e71-f3b646011377
- DOI
- 10.17638/03062803