Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment.

Abstract excerpt

We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice that is oxygenated by a single blood vessel. Phenotype is identified with the stemness level of a cell and determines its proliferative capacity, apoptosis propensity and response to treatment. Our study is based on numerical bifurcation analysis and dynamical simulations of a system of coupled, non-local (in...

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