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Article

Metabolic reprogramming and two-compartment tumor metabolism

24 Aug 2012

Abstract excerpt

Hypoxia-inducible factor (HIF) 1α and 2α are transcription factors responsible for the cellular response to hypoxia. The functional roles of HIF1α and HIF2α in cancer are distinct and vary among different tumor types. The aim of this study was to evaluate the compartment-specific role(s) of HIF1α and HIF2α in breast cancer. To this end, immortalized human fibroblasts and MDA-MB-231 breast cancer cells carrying...

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PMID: 22894905
DOI: 10.4161/cc.21643

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